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How Did You Go About Formulating Your Research Hypothesis?

Alternative Ways of Asking:

  • How did you develop the idea for your research?

  • Can you walk me through your thought process when determining your research question?

  • What influenced you to select this particular hypothesis for your study?

  • Describe the steps you took in deciding on your research hypothesis.

  • How did you arrive at this specific research question or hypothesis?

  • What inspired or motivated you to focus on this research topic?

  • How did you refine or narrow down your initial ideas into a testable hypothesis?

Rationale and Importance:

Research in the medical field is crucial for continuous advancements in patient care and understanding of diseases. Formulating a research hypothesis serves as the foundation for the entire research project. It sets the direction and purpose. Residency programs are keen to know how candidates approach scientific problems, as this speaks volumes about their analytical skills, intellectual curiosity, and commitment to evidence-based medicine.


Moreover, understanding a candidate's approach to research formulation reflects their potential contribution to the medical community. Residents are often given opportunities to engage in research, and understanding their foundation in research can also predict their ability to contribute effectively to these projects. Consequently, the question is not merely about the hypothesis itself, but also about the physician's ability to think critically, demonstrate creativity, and approach problems methodically.


Things to Consider While You Answer:

  • Identify a problem or question of interest.

  • Conduct a literature review to understand current knowledge.

  • Identify gaps in the existing literature.

  • Develop a testable statement based on your findings and interests.

  • Refine the hypothesis ensuring it's specific, measurable, and achievable.

List of Common Mistakes Candidates Do:

  • Being overly vague or broad about their research interests.

  • Not demonstrating a clear understanding of their own research.

  • Failing to mention the importance of literature reviews in hypothesis formulation.

  • Only discussing results and not the formulation process.

  • Not acknowledging or being aware of potential limitations in their research.

Time Frame for Providing an Answer: less than 60 seconds


Sample Answers:

Sample Answer 1: In my final year of med school, I was particularly intrigued by the increasing rate of antibiotic resistance. Through extensive literature review, I noticed a gap in our understanding of natural resistance mechanisms in certain bacteria. I decided to hypothesize that certain bacteria might possess inherent protective mechanisms independent of prior antibiotic exposure. With guidance from my mentors, I refined this hypothesis and structured my research around it.


Sample Answer 2: During my rotations, I observed a pattern of post-operative complications in patients with diabetes. I began questioning if glycemic control played a role in surgical outcomes. I was particularly interested in surgical outcomes between medication induced glycemic control versus glycemic control by low carbohydrate diet and medication. I delved into existing literature, and while there was some indication of a relationship, the data was inconclusive. This drove me to hypothesize that strict perioperative glycemic control with combination of low carb diet and medication could reduce complication rates compared to medication alone. My research was an exploration into this correlation.


Sample Answer 3: My interest in pediatric oncology was the foundation for my research. I noticed varying treatment outcomes among patients, even with similar diagnoses and treatment regimens. I reviewed available literature to understand potential factors. A gap existed in the potential influence of genetic polymorphisms on treatment outcomes. Thus, I hypothesized that specific genetic markers could predict treatment responsiveness in pediatric cancer patients.


Sample Answer 4: The rising cases of mental health issues among adolescents caught my attention. I was curious about environmental factors contributing to this trend. I researched extensively and found limited studies on the impact of digital device usage on adolescent mental health. This led me to hypothesize that prolonged exposure to digital screens could potentially increase stress levels in adolescents, and my subsequent research was structured around this theory.

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